Serum Interleukin-6 and Tumor Necrosis Factor-α Concentrations in Children with Mycoplasma Pneumonia

• Main Authors: Hsieh Chia-Chang, 謝佳璋
• Other Authors: Tsai Chang-Hai
• Format: Others
• Language: zh-TW
• Published: 2002
• Online Access: http://ndltd.ncl.edu.tw/handle/11717316383276875300

碩士 === 中國醫藥學院 === 醫學研究所 === 90 === A prospective study was performed to assess the relationship among C-reactive protein (CRP), interleukin—6 (IL-6), tumor necrosis factor-α (TNF-α) serum concentrations and the outcome of mycoplasma pneumonia in children. Serum samples were obtained from 49 children with mycoplasma pneumonia in the first day of admission. The mycoplasma pneumonia was diagnosed by chest film, anti-Mycoplasma pneumoniae antibody particle agglutination screening test and anti-Mycoplasma pneumoniae IgM antibody enzyme-linked immunosorbent assays (ELISA) confirming test. The serum concentrations of IL-6 and TNF-α were measured by ELISA and the serum concentrations of CRP were measured by immunonephelometry. IL-6 concentrations of mycoplasma pneumonia patients with fever > 3 days (41.98±67.46 pg/mL) are significantly higher than those in patients with fever  3 days (10.01±11.74 pg/mL) (P<0.05). CRP concentrations of mycoplasma pneumonia patients with fever > 3 days (4.86±3.43 mg/dL) are significantly higher than those in patients with fever  3 days (1.23±1.24 mg/dL) (P<0.05). The serum CRP levels are correlated to serum IL-6 levels (r=0.7, p＜0.05), but not correlated to serum TNF-α levels (r=0.11, p=0.43). These results suggest that IL-6 serum concentrations, rather than TNF-α, may be a potential indicator of the severity of mycoplasma pneumonia.