| Summary: | 碩士 === 國立陽明大學 === 傳統醫藥學研究所 === 89 === Abstract
The purpose of this study was to investigate the therapeutic effects of octreotide alone or in combination with tetrandrine on anesthetized portal hypertensive rats. Portal hypertension was induced by bile duct ligation (BDL, with cirrhosis) or portal vein ligation (PVL, without cirrhosis) in Sprague- Dawley rats.
In Study 1: Each BDL rat received only one of the two regimens: octreotide 8 microg/kg/hr for 30 min followed by tetrandrine 3.33 mg/kg/min for 3 min or octreotide 8 microg/kghr for 30 min followed by vehicle 0.1N HCl. In Study 2: The same protocols as Study 1，except the regimen of octreotide being 16 microg/kg/hr, while in study 3, octreotide 16 microg/kg/hr followed by tetrandrine 3.33 mg/kg/min was performed in PVL rats.
Infusion of octreotide (8 microg/kg/hr for 30 min) induced significant reduction of PVP (portal veinous pressure) (-6.9+/- 5.2%) from baseline, and octreotide followed by tetrandrine induced significant reduction of PVP (-19.0 6.3%) as well as MAP (mean arterial pressure) (-22.1+/- 8.9%). Compared with octreotide followed by vehicle, tetrandrine enhanced portal hypotensive effects of octreotide and induced significant reduction of MAP.
Infusion of octreotide (16 microg/kg/hr for 30 min) induced significant reduction of PVP (-9.9+/-5.5%) from baseline. Infusion of octreotide followed by tetrandrine induced significant reduction of PVP (-19.9+/-6.6%) as well as MAP (-28.6+/-6.3%). Similar effects were also found in PVL rats.
Our results suggested that octreotide, alone or in combination with tetrandrine, induced portal hypotensive effects in BDL or PVL rats. Tetrandrine significantly enhanced portal hypotensive effects of octreotide and induced significant reduction of MAP in BDL and PVL rats.
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