Therapeutic Effects of Chinese Medicine on Ischemic Stroke-A Study of Cerebral Active Regimens

• Main Authors: Kan I-Hung, 甘宜弘
• Other Authors: Prof. Chiu Wen-Ta
• Format: Others
• Language: zh-TW
• Published: 2001
• Online Access: http://ndltd.ncl.edu.tw/handle/97477936289105154448

碩士 === 台北醫學院 === 醫學研究所 === 89 === Stroke is the leading cause of handicaps in Taiwan. It can be diagnosed at the very ealiest time when the cerebral artery is occluded. However, there is no any drug proven to be clinically effective in the protection of the ischemic brain. Many Chinese herbs have been used for treating stroke for more than thousands of years. But no one has been proven scientifically to be effective. The purpose of this study was to test scientifically in stroke animals with 15 Chinese herbs which have been considered effective Chinese medicines for treating stroke patients, so that we could find out some potential useful Chinese herbs for clinical use in stroke patients. Sprague-Dawly rats weighing 450+50g were used. In the first stage, these animals were divided into 16 groups. Each group of animals were fed for 3 days with one kind of Chinese herb medicine chosen from lists of the more frequently and effectively used by Chinese herb medical doctors for treating stroke patients. The control group was fed with saline. Thereafter, the animals were anesthetized and subjected with a transient occlusion of the carotids and the right middle cerebral arteries for 1 hour. The brains of these animals were perfused with saline and stained for 30 minutes with 2% TTC 48 hours after brain reperfusion. Our results showed that the brain infarction volume of the control animals was 203+9.03 mm3 (mean+SEM). The mean infarction volumes of the groups treated with the 15 herb medicines were listed in Table 1. and figured in Figure 1. Among the 15 treatment groups, five had significant lower infarction volume than the control. Liu Hung Wang (牛黃丸), Yu San Wang (育生丸), Siu Su Ming Tang (小續命湯), Hung Chi Wu Wu Tang (黃耆五物湯), and San Fu Tang (參附湯) were effective in prevention of ischemic brain injury. In the second stage, those animals were divided into 6 groups. Five groups of animals underwent ligation procedures and the other one as control. Five ligation groups were fed for 2 days with one kind of 5 effective Chinese herb medicines demonstrated in the first stage of the experiment and the control group fed with normal saline. The results of the second stage showed that two groups had significant lower infarction volume than the control group. The mean infarction volumes of the groups treated with the five herb medicines were listed in Table 2. and figured in Figure2. In conclusion, San Fu Tang (參附湯)、Yu San Wang (育生丸) deserved further investigation for clinically treating ischemic brain injury. Key words: stroke, cerebral ischemia, infarction volume, Chinese herb