Synthesis of 5-Methyl-2-substituted-2H-pyrazol-3-yl-amine Derivatives

• Main Authors: Su Chih-Wen, 蘇志文
• Other Authors: Wang Ing-Jing
• Format: Others
• Language: zh-TW
• Published: 2001
• Online Access: http://ndltd.ncl.edu.tw/handle/67023478991124518308

碩士 === 國立臺灣科技大學 === 纖維及高分子工程系 === 89 === In this study, the reaction of acetoacetamide with hydrazine hydrate and phenyl hydrazine was shown to give compounds 3a and 3b. First, the reaction of compounds 7a~7b and 11a~11b with a solution of compounds 3a and 3b in water by nitrosation at position 4 in low temperature, and were coupled with aromatic benzylamine derivatives. Second, the reaction of compound 3a with ethyl acetoacetate, acetoacetamide, phthalic anhydride and nitric acid was shown to give compounds 17, 23, 27 and 30. Third, a solution of compound 3b in ethanol was condensed with aromatic aldehyde derivatives and aromatic nitrosobenzene derivatives by presence of basic catalyst was shown to give compounds 32a~32d and 34a~34b. Finally, these compound were determined the structure by spectrometry（UV、FTIR、1H-NMR） and element analysis（EA）.