Changes of cariogenic microflora in children receiving chemotherapy

• Main Authors: Wang Yin-Lin, 王姻麟
• Other Authors: Guo Ming-Kuang
• Format: Others
• Language: zh-TW
• Published: 2001
• Online Access: http://ndltd.ncl.edu.tw/handle/72031031591533499221

碩士 === 國立臺灣大學 === 臨床牙醫學研究所 === 89 === Twenty acute leukemia children with being treated with cytotoxic chemotherapy at National Taiwan University Hospital, were examined between 6 months and 1 year to determine the changes in their oral conditions. They were examined before treatment commenced and then at planned intervals. Caries index, plague index and gingival index were recorded. Unstimulated saliva sample were used to access levels of bacteria in oral carity. All children received prophylactic nystatin four times daily for the treatment periods. Chlorhexidine gluconate mouthrinses were recommended for uses in oral hygiene care. There was significant difference ( p < 0.05 ) for counts of S. mutans at different treatment stages. Sensitivity tests showed that S. mutans was sensitive to the cytotoxic drugs idarubicin and methotrexate. These two drugs and chlorhexidine were probably responsible for the fall in S. mutans counts. Significant differences were also found in the counts of S. mutans and lactobacillus between the study and reference groups before chemotherapy. Untreated caries cavities may contributed to the results. Though decreases in the counts of caries-related bacteria were found, it was still important to keep intensive oral hygiene care for oncology children.