| Summary: | 碩士 === 國立臺灣大學 === 獸醫學研究所 === 89 === Leptospirosis patients may show influenza-like clinical symptoms, and always have been disregarded by the physicians in Taiwan. In order to realize the transmission and present situations of leptospirosis in Taiwan, the study is divided into two parts. The first part focuses on the detection of antibody to different serovars and pathogen isolation among workers, pigs, rats and other animals in piggery. The results are used to analyze of disease transmission routes in the piggery, and give recommendations to disease prevention. Due to the epidemic period and clinical symptoms between leptospirosis and the dengue fever are very similar, and therefore mis-diagnosed or under-diagnosed. The second part aims at the 227 negative sera (186 cases) submitted to Center of Disease Control (CDC) dengue fever surveillance system which were collected from August to December, 2000. The purpose of this investigation is to understand the under-diagnosesd status of leptospirosis. The results revealed all the leptospires isolated from rats were identified as belonging to the poi serovar, which were different to the prevailing serovars, namely shermani in piggery workers and serovars shermani, bratislava in pigs. This excludes the possible role of rats as sources of infection in the piggery. The seroprevalence of negative sera in dengue surveillance system is 23%(42/186), the prevalent serovars are shermani, bratislava and hebdomadis. The seroprevalence is significantly lower in the current leptospirosis surveillance system, which is 16% (17/108), the prevalent serovars are shermani, tarassovi and bratislava. The major two reacting serovars shermani and bratislava are common between in these two systems. However, the higher geometric mean titer appears in other serovars. Physicians should consider leptospirosis in the dengue suspected patients. Continue serological survey and more pathogen isolation works are required for elucidating the true epidemiological status of leptospirosis in Taiwan.
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