Drug delivery by ultrasound-controlled liposome cavitation: System and technical requirements

• Main Authors: Po-Lin, Chiu, 邱柏霖
• Other Authors: Jen-Ho Tsao
• Format: Others
• Language: zh-TW
• Published: 2001
• Online Access: http://ndltd.ncl.edu.tw/handle/20251567223449963711

碩士 === 國立臺灣大學 === 電機工程學研究所 === 89 === Abstract Drug delivery system with ultrasound has widely been used in clinical therapy, for example, transdermal drug delivery, and sonodynamic therapy, etc. Good drug delivery system requires the suitable administration pathway, targeting to the diseased organ, increased drug efficacy and reduced side effects. We will set up and evaluate a new drug delivery system to control drug release by using ultrasonic cavitation and drug carrier as liposome. In this study, we will produce our drug carrier — liposome, and obtain the optimal conditions of cavitation occurrence by analyzing and processing the reflective acoustic signal of liposomes in order to make liposomes collapse around the diseased organ or tissue. We change the experimental conditions, for example, transmitting cycles, PRF length, transmitting acoustic amplitude and frequency, etc., in order to obtain the optimal conditions of liposome detection and cavitation. Finally, we will discuss the technical requirements of this drug delivery system, and its safety and applications.