Nephrotoxicity and Myelosuppression Induced by Cisplatin Administrations in Different Saline Concentrations in Dogs

• Main Authors: CHO-CHIA HUANG, 黃卓智
• Other Authors: 吳永惠
• Format: Others
• Language: zh-TW
• Published: 2001
• Online Access: http://ndltd.ncl.edu.tw/handle/14335270281674366889

碩士 === 國立屏東科技大學 === 獸醫學系 === 89 === In order to compare the cisplatin-induced nephrotoxicity and myelosuppression in different saline concentration vehicles with multiple cisplatin administrations, eighteen apparently healthy-Beagle dogs were used dividing into 3 groups; Two of these groups were infused with 4 doses of cisplatin 70 mg/m2 which were distilled in 0.9% and 3.0% saline at 21 days intervals, respectively. And the control group was infused with 0.9% or 3.0% saline only. Based on results of the serum urea nitrogen, creatinine concentrations and clearance tests of creatinine, the 0.9% saline vehicle group showed less toxic to the kidneys comparing to the 3.0% saline vehicle group after receiving the third dose. From results of the urine concentration test and renal histopathological finding, the 0.9% saline-vehicle group also revealed less toxic to the renal tubules than the 3.0% saline-vehicle group after receiving four doses of cisplatin administration. Anemia was not evident in both of 0.9% and 3.0% saline-vehicle groups throughout the whole experiment. Transient and mild to moderate degree of neutropenia and thrombocytopenia was definitely found at the second week after each dose of cisplatin administration. Besides, there was no significant difference between 0.9% and 3.0% saline-vehicle groups in the rate and the level of onset and recovery of neutropenia and thrombocytopenia. According to the above results, we suggest 0.9% saline as the vehicle is more suitable than 3.0% one with multiple doses of cisplatin administration for dogs.