The Application of Supercritical Carbon Dioxide in the Micronization of Meloxicam

• Main Author: 陳彰儀
• Other Authors: WANG DA-PENG
• Format: Others
• Language: zh-TW
• Published: 2001
• Online Access: http://ndltd.ncl.edu.tw/handle/15732586460803938824

碩士 === 國防醫學院 === 藥學研究所 === 89 === Applications of supercritical carbon dioxide for processing of pharmaceuticals are more and more studied in the recent years. Of all the studies, the micronization technology of supercritical carbon dioxide is one method to investigate reducing the particle size of drugs. RESS（rapid expansion of a supercritical solution）, one system of micronization technology of supercritical carbon dioxide, has been used to reduce particle size of the poorly water soluble drugs and enhence the dissolution rate. Meloxicam, a water-insoluble NSAID, was micronized with RESS system in this study. The influences of temperature and pressure on the particle size and on the drug content in water-soluble polymer are investigated in this study. In the results, the particle size of meloxicam is reduced from 42.04 μm to 1.02 μm and is narrow distributed. The operating factors influenced on the drug’s content of coprecipitates of meloxicam and PEG 4000 are evaluated. The results show that the drug’s content of the coprecipitates is increased by temperature and decresed by pressure. The addition of cosolvent also improve the drug’s content of the coprecipitates. Finally, we get the powder with 4.679 % meloxicam （w/w）under the condition of 100 ℃, 170 bar and adding 0.8 ml ethanol.