開發單一步驟的簡便的的合成法,Pulchellalactam,天然抑制劑之合成

• Main Author: 蔡林松
• Other Authors: 李文仁
• Format: Others
• Language: zh-TW
• Published: 2001
• Online Access: http://ndltd.ncl.edu.tw/handle/33987004447734341635

碩士 === 國立中央大學 === 化學研究所 === 89 === 英文摘要 A general and successful N-terminal attachment methodology is described that allows the solid phase synthesis of oligopeptides from activated N-hydroxysuccinimide esters and amino acid lithium salts. The results of studies with different coupling systems for amide bond formation are presented. The oligomers were synthesized on solid support using a carbamate linker with final TFA/CH2Cl2 cleavage. This methodology was also applies for the preparation of peptide-substituted amides and esters in high purities and excellent yields. Numerous and specific inhibitors of PTKs have been discovered and tested as therapeutic agents against human disease. Currently, there are few readily available potent inhibitor of CD45 protein tyrosin phosphatase. CD45, has been shown to play crucial roles in activation of B and T cells. CD45 therefore represents a terapeutic target for various auto-immune and chronic anti-inflammatory diseases. We have completed the synthesis of Pulchellalactam, and we can change two different functional group for searching the best inhibitor.