| Summary: | 碩士 === 高雄醫學大學 === 行為科學研究所 === 89 === Evidences show that different brain areas involve in the different forms of learning for a similar task. The brain may posses multiple memory system that enables the organism to learn the similar task via different information encoding processes. The aim of this study was to determine the role of hippocampus and striatum on memory acquisition, formation and retrieval in two water maze learning. In experimentⅠ, the rats were injected DL-2-amino-phosphonopentanoic acid (AP5), the N-methyl-D-Aspartate receptor (NMDA receptor) antagonist, intra-hippocampally or intra-striatally before water maze learning. They were trained with spatial water maze and cued water maze tasks for two days, respectively. The rats were tested for their memory 24 hours later. In experiment Ⅱ, the rats were injected immediately after learning. In experiment Ⅲ, the rats were injected before the memory testing. The controlled rats for all experiments were injected with saline instead. The results show that the pre-training and post-training AP5 intra-hippocampal injected rats impaired in memory acquisition and formation on the spatial water maze task, respectively. In contrast, the pre-training and post-training AP5 intra-striatal injected rats impaired in the memory acquisition and formation on the cued water maze task, respectively. No differences were found in the pre-testing injected rats. The present findings indicate that both hippocampus and striatum process different forms of learned information during the stages of acquisition and formation, which may activated via NMDA receptors. These indicated the different forms of memory share a similar physiological mechanism.
Keywords: AP5, hippocampus, striatum, memory acquisition, memory formation, memory retrieval, spatial water maze, cued water maze
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