Synthesis of Novel N-Acetyl-N-hydroxy amino Thymidine Derivatives

碩士 === 朝陽科技大學 === 應用化學系碩士班 === 89 === Abstract In this thesis we discuss on the synthesis of compound 42 ,which contains bicyclic deoxynucleose. Two other new compounds, 20 and 21,were obtained during the synthesis process. By applying Mitsunobu...

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Bibliographic Details
Main Authors: CHUNG FEN YU, 鍾芬裕
Other Authors: 楊德芳
Format: Others
Language:zh-TW
Published: 2001
Online Access:http://ndltd.ncl.edu.tw/handle/61563394564179423330
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Summary:碩士 === 朝陽科技大學 === 應用化學系碩士班 === 89 === Abstract In this thesis we discuss on the synthesis of compound 42 ,which contains bicyclic deoxynucleose. Two other new compounds, 20 and 21,were obtained during the synthesis process. By applying Mitsunobu method , we have synthesized compound 43. The acetyl group of compound 43 was then hydrolyzed and became compound 42. By cooperating with pharmacologists , we are now evaluating the biological activities of these compounds. We hope that some useful compounds could be successfully derived, which could then be applied to clinical therapies in the near future.