Inhibitory Effect of Phenylacetylmethionines and Related Compounds on Methionine Adenosyltransferase

• Main Authors: Chang, Yu-Hsun, 張昱勛
• Other Authors: 郭盛助
• Format: Others
• Language: zh-TW
• Published: 2001
• Online Access: http://ndltd.ncl.edu.tw/handle/21604329064510210528

碩士 === 中國醫藥學院 === 藥物化學研究所 === 89 === Cell differentiation agent II (CDA-II), phenylacetylamino acid derivatives and related compounds were examined as potential inhibitors of methionine adenosyltransferase II (MAT II) using radioisotope analysis method. Ming-26-L (M26), Ming-27-D (M27), D-methionine, penicillin G and ethanol with significant inhibitory activity were identified. The kinetic behavior of these compounds for MAT were studied using fluorometric method. The results indicated that D-methionine was a competitive inhibitor of MAT with respect to L-methionine. The achievement supply us to establish the phamacophore of MAT inhibitors.