| Summary: | 碩士 === 中國醫藥學院 === 環境醫學研究所 === 89 === The number of cancer patients increasing the amount of antineoplastic drugs applied on cancer patients is increasing day by day in hospital. The proper disposal those hazard wastes become to a very important issue. The purposes of our investigation are as following: 1. To investigate either the total amount or percentage of the antineoplastic chemical waste in hospital waste and the residual concentration of drug in the waste as the referable database for waste management. 2. To investigate the current conditions of the storage, transportation and management. 3.To investigate the possibility of thermal process to treat for destruction of chemotherapeutic drug as a referable database for incineration.
1. Questionnaires designation for the amount of common chemotherapeutic drug in which 5-Fu was chosen for concentration and residual amount analyses using HPLC. 2. 5-Fu was also used as a model chemotherapeutic drug to perform the TG pyrolysis under a nitrogen atmospheric at temperature ranging of 400-900 k at the nominal rates of 1.0, 3.0, and 5.0 K/min. Further incineration experiment was carried out in a closed system with gasoline added as an auxiliary fuel. 3. The formation of VOCs from the pyrolysis process was analyzed by mass spectrometry to understand the possible gas composition during incineration.
1. In general, every patient produced approximately 0.11-0.23 Kg of chemotherapeutic wastes per day during the course of chemotherapeutic process or 600-1000 Kg of chemotherapeutic wastes per month in a hospital. This is corresponding to about 1.68% of total infection wastes. The drugs can be presence as the residue within vial and bottle waste of chemotherapeutic treatment, in which the average concentration was 1702 mg/kg waste or corresponding to 177-335 Kg in net. 2.A significant mass reduction was calculated from the dynamic TG 5-Fu mass reducing curve, all three heating rates, the vaporization and pyrolysis begin at the temperature of 460K , 90 percentage of experiments has completed the vaporization pyrolysis during the temperature ranged from 460-673K. 3.In the result of incineration, pyrolysis of chemotherapy drug complete in the initial 200 sec. The highest temperatures of pyrolysis of 5-Fu , cisplatin, MTX are 629℃, 717℃ and 612℃. The mole number of these three drugs present with stability is also showed after 200 sec. 4.According to the molecular weight , gas content is component with CO2, CO, O2, in the gas analysis after pyrolysis of 5-Fu , cisplatin, MTX . An unknown subject which molecular weight is 70 was found in MTX series . More exploration is necessary.
In comparison of the temperature of TGA pyrolysis ranging from 200℃-400℃,the temperature of pyrolysis of chemotherapeutic drug is ranging from 200℃-600℃ in the combustion fuel experiment .So, when the chemotherapeutic drug waste is thrown to the 1°incinerator of medical waste incinerators, the combustion and pyrolysis would complete without hazard gas production.
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