Effect of Rhizoma Corydalis on Cerebral Infarct in Ischemia-Reperfusion Injuried Rats

• Main Authors: En-Tzu Liao, 廖恩賜
• Other Authors: C.L. HsieH
• Format: Others
• Language: zh-TW
• Published: 2001
• Online Access: http://ndltd.ncl.edu.tw/handle/40687719353344943415

碩士 === 中國醫藥學院 === 中國醫學研究所 === 89 === Effect of Rhizoma Corydalis on Cerebral Infarct in Ischemia-reperfusion Injuried Rats EN-SZU LIAO Institute of Chinese Medical Sciences,China Medical College Abstract According to the theory of Traditional Chinese Medicine，cerebral infarction results from blood stasis，and the method of quickening the blood and dispelling stasis is used to treat cerebral infarct.Rhizoma Corydalis(RC) is a Chinese herb which is considered to have a action of quickening the blood and dispelling stasis.The aim of the presnt was to investigate the effect of RC on cerebral infarct in ischemia-reperfusion injuried rats.The model of focal cerebral infarct was developed by occluding the bilateral common carotid arteries and the right middle cerebral artery for 90 min. After 24 hrs reperfusion,evaluated the neurological status and then the rats were killed and the brain tissue was stained with 2,3,5-triphenyl-tetrazolium chloride(TTC).The areas of cerebral infarct were calculated,and the change in the area of cerebral infarct were used as an index to evaluate the of RC on cerebral infarct.The results indicated that pretreatment with intraperitoneal injection of RC 50mg/kg and 100mg/kg reduce the area of cerebral infarct and 100mg/kg reduce the neurological defecit.Furthermore, RC won't effect the liver and renal function and increase red blood cell and heamatocrit . Our conclusion is that RC can reduce cerebral infarct area and neurological defecit of ischemia-reperfusion injuried rats,suggesting it may be useful in treatment of cerebral infarct in humam,especially in acute stage and the possible mechainisms are worth both laboratory and clinical study. Key Words:Stroke,Cerebral infarction,Infarct size,Rhizoma corydalis