| Summary: | 碩士 === 中國醫藥學院 === 中國醫學研究所 === 89 === The purpose of this study was to investigate the hemodynamic effects of of Huang-qi in anesthetized portal hypertensive rats. Portal hypertension was induced by partial portal vein ligation in Sprague-Dawley rats. The portal hypertensive rats were randomly divided into four groups to receive normal saline, propranolol（10mg/kg）, low dose crew extract of Huang-qi（0.1 g/kg）, and high dose crew extract of Huang-qi（1 g/kg）, respectively. The changes of portal vein pressure（PVP）, mean arterial pressure（MAP）and heart rate（HR）were observed. Statistical comparison was performed using the multivariate analysis of variance, general linear model’s procedure, and Duncan’s multiple comparison.
Infusion of low dose of Huang-qi increased HR, but showed no influence on PVP and MAP. Infusion of high dose of Huang-qi first induced elevation of PVP and MAP, and then followed by reduction slightly from baseline. HR was also increased in this group. The effects of Huang-qi are different from those of propranolol.
Our results suggest that the patients with liver cirrhosis should be more careful when taking high dose of Huang-qi.
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