| Summary: | 碩士 === 國立臺灣大學 === 流行病學研究所 === 88 === 英文摘要
Objectives：This study was carried out to investigate the associations of the polymorphisms of XRCC1 exon6,exon9,exon10,XRCC3 exon7,XPD exon23 and hMLH1 genes with lung adenocarcinoma in women. The interactions among polymorphisms of DNA repair genes of XRCC1, XRCC3, XPD and hMLH1 were also evaluated.
Methods：Genotyping was performed using PCR-based methods on peripheral leukocyte DNA.A total of 107 female lung adenocarcinoma cases and 263 female controls were genotyped for the polymorphisms of the DNA repair genes.
Results：After adjustment for age and schooling years,the odds ratio of developing adenocarcinoma was 1.7 for tobacco exposure, 2.4 for family history of lung adenocarcinoma,2.7 for not using ventilator in kitchen,3.4 for using lard as cooking oil (comapred with vegetable oil), and 3.4 for using coal and charcoal as cooking fuel (compared with electricity and natural gas).The multivariate-adjusted odds ratio of developing adenocarcinoma was 2.3（95﹪CI：1.1-4.6）for XRCC1 Gln/Gln genotype (compared with other genotypes),2.9（95﹪CI：1.6-5.1）for XPD exon23 Lys/Gln or Gln/Gln (compared with Lys/Lys genotype),and 3.8（95﹪CI：1.5-9.8）for hMLH1 GA or AA (compared with GG genotype).
Conclusions：Our results suggested that tobacco exposure、cooking fumes、family history of lung cancer were important risk factors for female lung adenocarcinoma。The polymorphisms in DNA repair genes including XRCC1 exon10、XPD exon23 and hMHL1 were associated with an increased risk of lung adenocarcinoma.
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