Application of Self-Contained Subsets Method to Estimation of Twin Concordance for Dichotomous Traits

• Main Authors: Yea-Li Hwang, 黃雅莉
• Other Authors: 戴 政
• Format: Others
• Language: zh-TW
• Published: 2000
• Online Access: http://ndltd.ncl.edu.tw/handle/10644980140736707597

碩士 === 國立臺灣大學 === 流行病學研究所 === 88 === Twin studies have wide applications in human behavior genetics. For binary traits there are several measures of association for the twin data, concordance is one of these measures. Estimation of concordance is useful in genetic counseling and inference of the genetic effect for a complex trait. There are two major types of concordance, pairwise concordance and casewise concordance. Currently the likelihood method is the principal approach to estimate the twin concordances. However, the direct derivation procedure for the estimates and its variances is very complicated. Based on the self-contained subsets method and the delta method, here we propose a direct and easier method for estimation of concordances and the variances. Basically, our results provide the same answer as that from the likelihood method.