Studies on the significance of MMP in Leukemia

• Main Authors: Cheng-Yeh Lee, 李承曄
• Other Authors: 林亮音
• Format: Others
• Language: zh-TW
• Published: 2000
• Online Access: http://ndltd.ncl.edu.tw/handle/47368897254542377193

碩士 === 國立臺灣大學 === 醫事技術學研究所 === 88 === Matrix metalloproteinase（MMP）which can degrade extracellular matrix are thought to play a critical role in tumor invasion and metastasis, however, there is little information on the evaluation of MMPs in leukemia. The purpose of this study is to evaluate the role of MMPs in leukemia. We compared the MMPs and TIMPs among patients with AML, ALL, CML as well as normal donors, and found that there was significant difference among various categories in MMP—9 level. Because MMPs and TIMPs didn’t show any difference among aleukemic leukemia patients, we concluded that MMPs and TIMPs might not have correlation with migration of immature cells. By using statistic analysis, it showed that the MMP—9 level at present of disease could be a prognostic marker for reaching complete remission and living longer. Although most patients had higher MMP—9 level when they are in complete remission state, there should be more ongoing data to evaluate whether MMP—9 could be a monitor of leukemia progression.