掌性催化劑1,1’-二乙氧羰基-2,2’-二羥基-4,4’-二甲基-3,3’-聯薁的合成研究

• Main Author: 袁守賓
• Other Authors: 陳阿煌
• Format: Others
• Language: zh-TW
• Published: 2000
• Online Access: http://ndltd.ncl.edu.tw/handle/08598418567901421964

碩士 === 國立高雄師範大學 === 化學系 === 88 === Abstract Asymmetric catalysis is one of the most challenging and formidable endeavor in organic synthesis. The development of chiral auxiliaries is a key in the asymmetric catalysis. 1,1'-Bi-2-naphthols(BINOLs) are known as one of the most useful chiral auxiliaries, especially for catalytic asymmetric reactions, enantioselective reduction of ketones, synthesis of chiral macrocycles, molecular recognition and nonlinar optical materials and so on. We have conducted to a study of development of chiral auxiliaries of BIAZOLs. The precurors of BIAZOLs, diethyl 4,6,8-trimethyl or phenyl-2-hydroxyazulene-1,3-dicarboxylates, were synthesized from dicyclopentadiene. They will be used for synthesis of BAZOLs.