| Summary: | 碩士 === 國立中興大學 === 化學工程學系 === 88 === In this research, a total of twelve poly(carbonate)urethanes (PCUs) were synthesized using four different soft macrodiols, and three hard/soft segment ratios. The four macrodiols include two from America CT Biomaterials (U.S.), as well as two from Japan Nippon Polyurethane Industry (Japan). The hard segment was 4,4’-disphenylmethane diisocyanate (MDI) and chain extender was 2-butene-1,4-diol (1,4-BDO).
Dynamic mechanical analysis demonstrated larger microphase seperation for poly(carbonate)urethanes with higher soft segment ratio. In the same soft segment series, the surface of PCU containing more soft segment (greater degree of microphase seperation) was more hydrophlic (i.e. higher surface energy) and easier for endothelial to adhere and proliferate.
In blood compatibility tests, PCU with greater degree of microphase and easier reduced the platelet adhesion and activation on the surface. This may be attributed to the preferential adsorption for albumin observed on these surfaces. Finally, in biostability tests for both in vitro (H2O2/Co2+) and in vivo (implantation in rats for three months), poly(carbonate)urethanes was found stable than poly(ether)urethanes.
Therefore, poly(cabonate)urethanes with their superior blood compatibility, cellular adhesion, and biostability could be better candidates for cardiovascular biomaterials. We expect to employ them in fabrication of the small-diameter vascular grafts and artificial skins.
|
|---|
