| Summary: | 碩士 === 高雄醫學大學 === 醫學研究所 === 88 === Complex segregation analyses were conducted on families of gout probands to delineate the mode of the inheritance. The probands were ascertained from the persons we had visited by door to door and the gout disease had been identified by a practical doctor. The analyses were based on data from 64 aboriginal families with 945 individuals living in Taiwan, and were performed by using the REGTL (Release 2.2) program of the SAGE (version 3.0) package. The gout information of adults was provided by themselves and that of children was from their parents. We used sex and age to adjust covariates. A single locus model fitted the data well, but none of the Mendelian models (recessive, dominant, and arbitrary) could be distinguished. The no-parent-offspring-transmission hypothesis was rejected. However, when we split the data into early-onset and late-onset, both Mendelian and environmental hypotheses relatively were rejected.
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