The developmental study of antioxidant activities on traditional Chinese prescriptions and several folk medicines in Taiwan

碩士 === 高雄醫學大學 === 天然藥物研究所 === 88 === The generation of oxygen radicals and the process of lipid peroxidation may be a factor in the cerebral damage secondary to the ischemia of the cerebrovascular disease (CVD),for example, stroke. The antioxidant activities of five traditional Chinese medicinal pre...

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Main Authors: Feng-Lin Yen, 顏峰霖
Other Authors: Chun-Ching
Format: Others
Language:en_US
Published: 2000
Online Access:http://ndltd.ncl.edu.tw/handle/38809733779667577013
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spelling ndltd-TW-088KMC000680042015-10-13T10:56:27Z http://ndltd.ncl.edu.tw/handle/38809733779667577013 The developmental study of antioxidant activities on traditional Chinese prescriptions and several folk medicines in Taiwan 傳統方劑與生藥之抗氧化活性資源開發研究 Feng-Lin Yen 顏峰霖 碩士 高雄醫學大學 天然藥物研究所 88 The generation of oxygen radicals and the process of lipid peroxidation may be a factor in the cerebral damage secondary to the ischemia of the cerebrovascular disease (CVD),for example, stroke. The antioxidant activities of five traditional Chinese medicinal prescriptions: Shiee-Fuu-Jwu-Iu-Tang (SFJIT), Oh-Yaw-Shuen-Chin-Saan (OYSCS), Buu-Yang-Hwan-Wuu-Tang (BYHWT), Sheau-Shiuh-Ming-Tang (SSMT) and Chir-Hwu-Jia-Long-Guu-Muu-Lih-Tang (CHJLGMLT) were investigated in anti-lipid peroxidation, anti-superoxide formation and free radical scavenger activity, which were examined by means of FeCl2-ascorbic acid induced lipid peroxidation, xanthine oxidase inhibition, cytochrome C system and an electron spin resonance(ESR) spectrometer, respectively. The results showed that CHJLGMLT has more anti-lipid peroxidation and anti-superoxide formation effects than other prescriptions, CHJLGMLT showed the greatest superoxide radical scavenger activity and BYHWT showed the greatest hydroxyl radical scavenger activity.It is also proved that these prescriptions decreased the level of total cholesterol and LDL-cholesterol in serum on high cholesterol-fed rats. From these results, it seems likely that these prescriptions may be effective in the prevention and therapy of stroke which formed in the ischemic patients. Vitis thunbergii, Chrysanthemum morifloium, Hibiscus sabdariffa Rhinacanthus nasutus, Boehmeria nivea, Agastache rugosa, Peerilla frutescens Britten var, Luffa cylindrica, Gynostemma pentaphyllum, Haraella retrocalla, Mesona procumbens, Cacavalia gladiata, Ficus pumil, Houttuynia cordata, Ganoderma lucidum and Pteris ensiformis, are folk medicine in Taiwan, were investigated in anti-lipid peroxidation, anti-superoxide formation and free radical scavenger activity, which were examined by means of FeCl2-ascorbic acid induced lipid peroxidation, xanthine oxidase inhibition, cytochrome C system, respectively. The results showed that Gynostemma pentaphyllum, Vitis thunbergi, Chrysanthemum morifloium, Boehmeria nivea, have more anti-lipid peroxidation and superoxide radical scavenger effects than other crude drugs. Hibiscus sabdariffa, Ficus pumil, Vitis thunbergi, Chrysanthemum morifloium showed the greatest anti-superoxide formation activity. Chun-Ching 林 俊 清 2000 學位論文 ; thesis 78 en_US
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description 碩士 === 高雄醫學大學 === 天然藥物研究所 === 88 === The generation of oxygen radicals and the process of lipid peroxidation may be a factor in the cerebral damage secondary to the ischemia of the cerebrovascular disease (CVD),for example, stroke. The antioxidant activities of five traditional Chinese medicinal prescriptions: Shiee-Fuu-Jwu-Iu-Tang (SFJIT), Oh-Yaw-Shuen-Chin-Saan (OYSCS), Buu-Yang-Hwan-Wuu-Tang (BYHWT), Sheau-Shiuh-Ming-Tang (SSMT) and Chir-Hwu-Jia-Long-Guu-Muu-Lih-Tang (CHJLGMLT) were investigated in anti-lipid peroxidation, anti-superoxide formation and free radical scavenger activity, which were examined by means of FeCl2-ascorbic acid induced lipid peroxidation, xanthine oxidase inhibition, cytochrome C system and an electron spin resonance(ESR) spectrometer, respectively. The results showed that CHJLGMLT has more anti-lipid peroxidation and anti-superoxide formation effects than other prescriptions, CHJLGMLT showed the greatest superoxide radical scavenger activity and BYHWT showed the greatest hydroxyl radical scavenger activity.It is also proved that these prescriptions decreased the level of total cholesterol and LDL-cholesterol in serum on high cholesterol-fed rats. From these results, it seems likely that these prescriptions may be effective in the prevention and therapy of stroke which formed in the ischemic patients. Vitis thunbergii, Chrysanthemum morifloium, Hibiscus sabdariffa Rhinacanthus nasutus, Boehmeria nivea, Agastache rugosa, Peerilla frutescens Britten var, Luffa cylindrica, Gynostemma pentaphyllum, Haraella retrocalla, Mesona procumbens, Cacavalia gladiata, Ficus pumil, Houttuynia cordata, Ganoderma lucidum and Pteris ensiformis, are folk medicine in Taiwan, were investigated in anti-lipid peroxidation, anti-superoxide formation and free radical scavenger activity, which were examined by means of FeCl2-ascorbic acid induced lipid peroxidation, xanthine oxidase inhibition, cytochrome C system, respectively. The results showed that Gynostemma pentaphyllum, Vitis thunbergi, Chrysanthemum morifloium, Boehmeria nivea, have more anti-lipid peroxidation and superoxide radical scavenger effects than other crude drugs. Hibiscus sabdariffa, Ficus pumil, Vitis thunbergi, Chrysanthemum morifloium showed the greatest anti-superoxide formation activity.
author2 Chun-Ching
author_facet Chun-Ching
Feng-Lin Yen
顏峰霖
author Feng-Lin Yen
顏峰霖
spellingShingle Feng-Lin Yen
顏峰霖
The developmental study of antioxidant activities on traditional Chinese prescriptions and several folk medicines in Taiwan
author_sort Feng-Lin Yen
title The developmental study of antioxidant activities on traditional Chinese prescriptions and several folk medicines in Taiwan
title_short The developmental study of antioxidant activities on traditional Chinese prescriptions and several folk medicines in Taiwan
title_full The developmental study of antioxidant activities on traditional Chinese prescriptions and several folk medicines in Taiwan
title_fullStr The developmental study of antioxidant activities on traditional Chinese prescriptions and several folk medicines in Taiwan
title_full_unstemmed The developmental study of antioxidant activities on traditional Chinese prescriptions and several folk medicines in Taiwan
title_sort developmental study of antioxidant activities on traditional chinese prescriptions and several folk medicines in taiwan
publishDate 2000
url http://ndltd.ncl.edu.tw/handle/38809733779667577013
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