Vitamin B-6 intakes and status assessment in healthy elderly and elderly with chronic diseases

• Main Authors: Yeong-Yu Yan, 嚴永裕
• Other Authors: Yi-Chia Huang
• Format: Others
• Language: zh-TW
• Published: 2000
• Online Access: http://ndltd.ncl.edu.tw/handle/53055225044318720494

碩士 === 中山醫學院 === 營養科學研究所 === 88 === The purpose of this study was to assess vitamin B-6 intakes and status in healthy elderly and elderly with chronic diseases. Subjects were divided into 4 groups ( 28 healthy males, 11 males with chronic diseases, 29 healthy females, 26 females with chronic diseases). Each subjects completed a 24-h diet recall and food frequency questionnaire. Plasma pyridoxal 5’-phosphate (PLP) and pyridoxal (PL), erythrocyte alanine and aspartate aminotransferase activity coefficients (EALT-AC and EAST-AC) were measured. The mean total vitamin B-6 intake (B-6 supplementation was included) was higher than the 1998 US Dietary Reference Intakes (DRI) and current Taiwan Recommended Daily Nutrient Allowance (RDNA) in all groups. Vitamin B-6 intake only correlated with EAST-AC in the healthy males (r=-0.48, p<0.05) and the pooled (r=-0.21, p<0.05) groups. There were no significant differences in plasma PLP, EALT-AC, and EAST-AC between healthy and chronically-disease groups. Only healthy elderly women had mean plasma PLP concentration equal to the suggested value (>30 nmol/L). There was no effect of sex or healthy status on vitamin B-6 intake, plasma PLP and PL, and EALT-AC. Healthy subjects tended to have abnormal EAST-AC values (p=0.0134) than subjects with chronic diseases. Regression analyses indicated that the amount of B-6 required to normalize EAST-AC to the suggested value (1.8) is 2.34 mg. The high incidence of biochemical vitamin B-6 deficiency in our elderly appears more related to an altered metabolism of vitamin B-6 than to the dietary intake of protein and vitamin B-6, healthy status or sex. Elderly subjects who increase their B-6 intake from food or supplementation might improve their vitamin B-6 status.