Synthesis of Fluoro-2'-hydroxychalcone Analogs as Antiinflammatory Agents

Synthesis of Fluoro-2'-hydroxychalcone Analogs as Antiinflammatory Agents

碩士 === 中國醫藥學院 === 藥物化學研究所 === 88 === A series of fluoro derivatives of chalcone was synthesized and evaluated for their antiinflammatory activity by several screening assay. Most of those tested compounds showed significant antiinflammatory activity. Among...

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Main Authors: I-Hsuan Tseng, 曾亦萱
Other Authors: Sheng-Chu Kuo
Format: Others
Language:zh-TW
Published: 2000
Online Access:http://ndltd.ncl.edu.tw/handle/10337941382611809670
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spelling ndltd-TW-088CMCH05490032015-10-13T11:50:52Z http://ndltd.ncl.edu.tw/handle/10337941382611809670 Synthesis of Fluoro-2'-hydroxychalcone Analogs as Antiinflammatory Agents 合成氟二羥基查耳酮類緣化合物及做為抗發炎劑 I-Hsuan Tseng 曾亦萱 碩士 中國醫藥學院 藥物化學研究所 88 A series of fluoro derivatives of chalcone was synthesized and evaluated for their antiinflammatory activity by several screening assay. Most of those tested compounds showed significant antiinflammatory activity. Among them, 3, 4- difluoro-2-hydroxychalcone (9) and 3-fluoro-2-hydroxy-4- methoxychalcone (10) were the most promising agents which demonstrated impressive effects on neutrophil degranulation, neutrophil superoxide formation, and TNF-■formation in macrophage and microglial cells. These two compounds thus selected for further investigation. Sheng-Chu Kuo Li-Jiau Huang 郭盛助 黃麗嬌 2000 學位論文 ; thesis 0 zh-TW
collection NDLTD
language zh-TW
format Others
sources NDLTD
description 碩士 === 中國醫藥學院 === 藥物化學研究所 === 88 === A series of fluoro derivatives of chalcone was synthesized and evaluated for their antiinflammatory activity by several screening assay. Most of those tested compounds showed significant antiinflammatory activity. Among them, 3, 4- difluoro-2-hydroxychalcone (9) and 3-fluoro-2-hydroxy-4- methoxychalcone (10) were the most promising agents which demonstrated impressive effects on neutrophil degranulation, neutrophil superoxide formation, and TNF-■formation in macrophage and microglial cells. These two compounds thus selected for further investigation.
author2 Sheng-Chu Kuo
author_facet Sheng-Chu Kuo
I-Hsuan Tseng
曾亦萱
author I-Hsuan Tseng
曾亦萱
spellingShingle I-Hsuan Tseng
曾亦萱
Synthesis of Fluoro-2'-hydroxychalcone Analogs as Antiinflammatory Agents
author_sort I-Hsuan Tseng
title Synthesis of Fluoro-2'-hydroxychalcone Analogs as Antiinflammatory Agents
title_short Synthesis of Fluoro-2'-hydroxychalcone Analogs as Antiinflammatory Agents
title_full Synthesis of Fluoro-2'-hydroxychalcone Analogs as Antiinflammatory Agents
title_fullStr Synthesis of Fluoro-2'-hydroxychalcone Analogs as Antiinflammatory Agents
title_full_unstemmed Synthesis of Fluoro-2'-hydroxychalcone Analogs as Antiinflammatory Agents
title_sort synthesis of fluoro-2'-hydroxychalcone analogs as antiinflammatory agents
publishDate 2000
url http://ndltd.ncl.edu.tw/handle/10337941382611809670
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