Synthesis of Fluoro-2'-hydroxychalcone Analogs as Antiinflammatory Agents
碩士 === 中國醫藥學院 === 藥物化學研究所 === 88 === A series of fluoro derivatives of chalcone was synthesized and evaluated for their antiinflammatory activity by several screening assay. Most of those tested compounds showed significant antiinflammatory activity. Among...
| Main Authors: | , |
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| Other Authors: | |
| Format: | Others |
| Language: | zh-TW |
| Published: |
2000
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| Online Access: | http://ndltd.ncl.edu.tw/handle/10337941382611809670 |
| Summary: | 碩士 === 中國醫藥學院 === 藥物化學研究所 === 88 === A series of fluoro derivatives of chalcone was synthesized
and evaluated for their antiinflammatory activity by several
screening assay. Most of those tested compounds showed
significant antiinflammatory activity. Among them, 3, 4-
difluoro-2-hydroxychalcone (9) and 3-fluoro-2-hydroxy-4-
methoxychalcone (10) were the most promising agents which
demonstrated impressive effects on neutrophil degranulation,
neutrophil superoxide formation, and TNF-■formation in
macrophage and microglial cells. These two compounds thus
selected for further investigation.
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