| Summary: | 碩士 === 中國醫藥學院 === 中國醫學研究所 === 88 === The purpose of the study is to deal with the prescriptions for curing Jaundice in Shan-Han-Lun, Jin-Gui-Yao-Lueh and Wen-Bing-Tian-Bian, comparing their choleretic and anti-liver damage effects, in treating ANIT-induced experimental cholangiolitic hepatitis of Jaundice in Rats, and, by means of Jonker’s pathologically semi-quantitative analysis to observe and compare how these prescriptions can make improvement in the model’s pathological lesion.
The results demonstrate that: (1)in Shan-Han-Lun, when the dosage is 1g/kg, Zhi-Zi-Bo-Pi Tang(ZBT) has the best effect on improving liver cell damage and bile dust obstruction; when the dosage is 2g/kg, Ma-Huang-Lian-Qiao-Chi-Xiao-Dou Tang(MLT) and Yin-Chen-Hao Tang (YCT) have the effect of anti-liver damage, but ZBT cought make liver toxicity and hemolysis, therefore, the best dosage of the prescription is worth to research. (2)in Jin-Gui-Yao-Lueh, when the dosage is 1g/kg, Zhi-Zi-Da-Huang Tang(ZDT), Yin-Chen-Wu-Ling San(YWS) and Da-Huang-Xiao-Shi Tang(DXT) can make improvement of liver damage and choleretic effect, only the YWS can make improvement of bile dust obstruction; when the dosage is 2g/kg, the treatment effects of these prescriptions are better then the dosage is 1g/kg. Among these prescriptions, the best effect of treatment is DXT. Pathologically, the main protective effect of liver damage may because of attenuation of PMN infiltration to inhibit the liver damage. (3)in Wen-Bing-Tian-Bian, when the dosage is 1g/kg, Er-Jin Tang(EJT), Xing-Ren-Shi-Gao Tang(XST) and Lian-Qiao-Chi-Xiao-Dou Yin(LCY) can make improvement of liver damage, LCY has the best effect among three prescriptions and can make improvement of bile duct obstruction. Pathologically, the main effects are on attenuation of liver cell inflammation and PMN infiltration; when the dosage is 2g/kg, among these prescriptions, LCY has the best effect on improvement of liver damage, choleretic and bile duct obstruction. Pathologically, on the main protective effect of liver damage, XST and LCY can make improvement of liver cell inflammation and tissue necrosis.
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