Integration of Glucose Utilization and Glycogen Turnover in Rat Skeletal Muscle and Heart in vivo: Effects of Acute Exercise and Long-term Training
碩士 === 長庚大學 === 基礎醫學研究所 === 88 === ABSTRACT Glucose transport is generally thought to be a rate-limiting step for glucose utilization but our pre-experiment suggest the notion that glucose utilization may be mediated through glycogen turnover in vivo. However, the relations...
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| Format: | Others |
| Language: | zh-TW |
| Published: |
2000
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| Online Access: | http://ndltd.ncl.edu.tw/handle/85016795802090675922 |
| Summary: | 碩士 === 長庚大學 === 基礎醫學研究所 === 88 === ABSTRACT
Glucose transport is generally thought to be a rate-limiting step for glucose utilization but our pre-experiment suggest the notion that glucose utilization may be mediated through glycogen turnover in vivo. However, the relationship between glucose utilization and glycogen metabolism is not clear. Base on our previous work, we hypothesis that the utilization of free glucose may occur via glycogen turnover.
In this study, we intend to prove or refute our working hypothesis. To prove our hypothesis, relationship between glucose utilization and glycogen metabolism was examined in rat with acute exercise and long-term exercise training. The second purpose of this study was to determine the possible effects of epinephrine on net glucose uptake and glycogenesis in skeletal muscle and heart in long-term trained animals. The results presented strongly suggest that (1) glucose utilization in skeletal muscle during contraction and acute exercise may be mediated through glycogen turnover. (2) Glycogenesis in the skeletal muscle and heart can be mediated through different glycogen synthases. (3) Epinephrine effects on the glucose metabolism in skeletal muscle and heart may be regulated by different metabolic pathway.
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