The Study of Double Proton Transfer in Purine Derivatives；The Investigation of DNA Mutation Mechanism

• Main Authors: Wen-Sin Chen, 程文星
• Other Authors: Pi-Tai Chou
• Format: Others
• Language: zh-TW
• Published: 2000
• Online Access: http://ndltd.ncl.edu.tw/handle/04098940329499117233

碩士 === 國立中正大學 === 化學研究所 === 88 === Self - dimerization of 7-Azaindole has long been recognized for undergoing the excited - state double proton transfer (ESDPT) resulting in a large Stokes shifted emission. Such a simple ESDPT process, at molecular level, provides one possible mechanism for the mutation due to a "misprint " of a specific DNA base pair. Through the molecular design we have already explored the spectra and dynamics of proton-transfer propriety among 4-azabenzaimidazole (4ABI), 7-azaindoline (7AZD), 3-Formyl-7-Azaindole and 3-Cyano-7-Azainodole, etc. Unfortunately such 7AI analogues cannot really simulate the base pair molecule such as adenine in DNA. The goal of my research is to design and synthesize various derivatives of which are analogous to the base pair molecules of DNA such as purine and adenine; and to precede a series of spectroscopy and dynamics studies based on their corresponding absorption and fluorescence properties.