Poly(ethylene-co-vinyl alcohol) membranes for drug delivery system

• Main Authors: Yen-Shih Huang, 黃彥士
• Other Authors: Leo-Wang Chen
• Format: Others
• Language: zh-TW
• Published: 1999
• Online Access: http://ndltd.ncl.edu.tw/handle/99610940869396265174

碩士 === 國立臺灣大學 === 化學工程學研究所 === 87 === The polymer membranes for colon-specific drug delivery system were prepared by phase inversion method. The physical and chemical properties change was discussed in this study. The dense E2 membranes made of EVAL with dry process and IPA/Water as co-solvent were suitable for the application. The drug, 5-ASA, had little transport through the E2 membranes at pH 2.00. However, 5-ASA released more at pH 7.40. The permeability was risen from 0.034*10-3 at pH 2.00 to 0.184*10-3 cm2/hr at pH 7.40. There would be an electro-repulsion between 5-ASA and membranes at pH 2.00. Therefore, it might inhibit the release. However, the swelling properties of PVA membranes dominate the drug delivery. The electro-repulsion effects might be ignored and there was no difference between the drug releases at two pH values. In addition, the Lysine-modified E2 membranes had better drug release. The permeabilities were lager both at pH 2.00 (0.139*10-3 cm2/hr) and pH 7.40 (0.312*10-3 cm2/hr) than original. The study shows that the EVAL membranes are promising candidates for providing a colon-specific drug delivery.