Chemical Constituents and Cytotoxicity of Formosan Soft Coral Lobophytum crassum and Sarcophyton sp.

• Main Authors: Bao-Tzeng Huang, 黃寶增
• Other Authors: Chang-Yih Dun
• Format: Others
• Language: zh-TW
• Published: 1999
• Online Access: http://ndltd.ncl.edu.tw/handle/13400365253727657226

碩士 === 國立中山大學 === 海洋資源學系 === 87 === The methylene chloride and n-Hexane extracts of Formosan soft coral Lobophytum crassum (collected in Green Island of Taiwan) were found to exhibit significant cytotoxicity against P-388, KB, A549 and HT-29 cancer cell lines. Chromatographic purification let to the isolation of two cembranoid diterpenes and three steroids. They are lobodleolide (30) and compounds 75, 15, 18, 57. Compound 75 was isolated from natural sources for the first time. Purification of cytotoxic n-Hexane extracts of Formosan soft coral Sarcophyton sp. (collected in Green Island of Taiwan) led to the isolation of two know diterpenes, (+)isosarcophytoxide (63) and (+) isosarcophyine (64). Compounds 30,75, 18, 57,63 and 64 exhibited significant cytotoxicity against P-388 cancer cell line. Compound 15 was cytotoxic against H-29 cancer cell line. Compound 75 also showed cytotoxicity against KB, A549 and HT-29 cancer cell lines.