A Study of Lumbar Bone Mineral Density and Related Factors in a Taipei Local Hospital

• Main Authors: Yang KL, 楊昆龍
• Other Authors: Ko YC
• Format: Others
• Language: zh-TW
• Published: 1999
• Online Access: http://ndltd.ncl.edu.tw/handle/63968406615886862348

碩士 === 高雄醫學院 === 醫學研究所 === 87 === Objective: To study the relationship among bone mineral density and the related factors and obtain evidence to guide the prevention of osteoporosis. Method: Bone mineral density of lumbar spine in 254 healthy Taiwanese (91 men aged 21-81,mean 43.6 years; and 163 women aged 21-83, mean 46.7 years) were measured, and other markers ( including bone marker - alkaline phosphatase and lipid profile - triglyceride, cholesterol, HDL and LDL ) were measured as possible as we can. Result: (1) For adult male and female, the peak value of mean lumbar BMD in every decade occurred in those aged 21-30. In male, the lumbar BMD decreased slowly with age, but in female, which decreased markedly only after 50 years old. (2) In bivariate analysis of lumbar BMD, the female significant variables were age, body weight, body height and LDL/HDL ratio; and in female, the significant ones were age, body height and ALP. (3) In multiple linear regression of lumbar BMD, age, body weight, body height and LDL/HDL ratio were not significant variables in male, and age, body height and ALP were all significant in female. (4) The risk for osteoppenia or osteoporosis between both sexes and among different age groups was calculated using multiple logistic regression. The risk for osteopenia or osteoporosis among male was significantly greater than that among female ( OR=1.834; 95% CI, 1.000 to 3.362 ) after adjusting for age and BMI. The risk for osteopenia or osteoporosis among people aged 51-60 and >60 was significantly greater than that among people with age<51(OR=14.168; 95% CI, 5.125 to 39.167 and OR=15.045; 95% CI, 5.438 to 41.623 respectively) after adjusting for sex and BMI. And the risk for osteoporosis among people aged 51-60 and >60 was significantly greater than that among people with age<51(OR=21.249; 95% CI, 5.444 to 82.937 and OR=42.735; 95% CI, 11.404 to 160.143 respectively) after adjusting for sex and BMI. Conclusion: Sex and age were both significant predictors for bone loss, and which should be considered in the prevention of osteoporosis.