The Determination of Elements in the Serum and Tissue among Breast Tumor Patients

碩士 === 中國醫藥學院 === 環境醫學研究所 === 87 === Elements are vital to healthy functioning of body tissues. A surplus or lack of any element may have a detrimental effect on or interfere with immunological response, cell growth, pathological change and systemic organs. The objective of this study is...

Full description

Bibliographic Details
Main Authors: Chen Shu-fen, 陳淑芬
Other Authors: Kuo Hsien-Wen
Format: Others
Language:zh-TW
Published: 1999
Online Access:http://ndltd.ncl.edu.tw/handle/05064317388461133349
id ndltd-TW-087CMCH0520009
record_format oai_dc
spelling ndltd-TW-087CMCH05200092016-02-03T04:32:22Z http://ndltd.ncl.edu.tw/handle/05064317388461133349 The Determination of Elements in the Serum and Tissue among Breast Tumor Patients 乳房腫瘤患者血清及組織中元素之分析 Chen Shu-fen 陳淑芬 碩士 中國醫藥學院 環境醫學研究所 87 Elements are vital to healthy functioning of body tissues. A surplus or lack of any element may have a detrimental effect on or interfere with immunological response, cell growth, pathological change and systemic organs. The objective of this study is to determine the elements in serum and tissue in breast tumor patients. The concentration of 15 elements in breast tumor cells were compared the concentrations in normal cells. This study can be used to start a database in Taiwan of element concentration in tissue and serum. All elements in serum and tissue were pretreated using microwaves and then analyzed using ICP-AES and AAS. The results showed that the concentrations of all 15 elements in tissue and serum were higher in breast tumor cells than in normal cells. The ratio of Cu/Zn increased with pathology of tumor cells. This ratio may be used as diagnostic tool for breast cancer. There are positive correlation between sera and tissues in Cr (r=0.37), Al (r=0.38) and ratio of Cu/Zn (r=0.36) from benign patients but only found in Al(r=0.43) from malignant breast tumor patients. Concentration of Zn, Cd, Cr, Al and Cu had statistical difference in different age strata. Based on the multiple regression, Zn concentration was higher in breeding or subjects who smoking compared to non-breeding and nonsmoker, respectively. There is a higher Mg concentration in sera among subjects with experience to nutrient taking. Compare tumor tissue to normal tissue, all element concentrations and ratios of Cu/Zn and Cu/Zn had significant difference. However, concentration of Cr, Mn, Fe, Mg and Al had significant difference between begin tissue and normal tissue. The authors suggest that further studies be conducted to establish a norm value of elements in human tissue in Taiwan in order to understand the relationship between tumor pattern and elements in human tissue and sera. Kuo Hsien-Wen 郭憲文 1999 學位論文 ; thesis 95 zh-TW
collection NDLTD
language zh-TW
format Others
sources NDLTD
description 碩士 === 中國醫藥學院 === 環境醫學研究所 === 87 === Elements are vital to healthy functioning of body tissues. A surplus or lack of any element may have a detrimental effect on or interfere with immunological response, cell growth, pathological change and systemic organs. The objective of this study is to determine the elements in serum and tissue in breast tumor patients. The concentration of 15 elements in breast tumor cells were compared the concentrations in normal cells. This study can be used to start a database in Taiwan of element concentration in tissue and serum. All elements in serum and tissue were pretreated using microwaves and then analyzed using ICP-AES and AAS. The results showed that the concentrations of all 15 elements in tissue and serum were higher in breast tumor cells than in normal cells. The ratio of Cu/Zn increased with pathology of tumor cells. This ratio may be used as diagnostic tool for breast cancer. There are positive correlation between sera and tissues in Cr (r=0.37), Al (r=0.38) and ratio of Cu/Zn (r=0.36) from benign patients but only found in Al(r=0.43) from malignant breast tumor patients. Concentration of Zn, Cd, Cr, Al and Cu had statistical difference in different age strata. Based on the multiple regression, Zn concentration was higher in breeding or subjects who smoking compared to non-breeding and nonsmoker, respectively. There is a higher Mg concentration in sera among subjects with experience to nutrient taking. Compare tumor tissue to normal tissue, all element concentrations and ratios of Cu/Zn and Cu/Zn had significant difference. However, concentration of Cr, Mn, Fe, Mg and Al had significant difference between begin tissue and normal tissue. The authors suggest that further studies be conducted to establish a norm value of elements in human tissue in Taiwan in order to understand the relationship between tumor pattern and elements in human tissue and sera.
author2 Kuo Hsien-Wen
author_facet Kuo Hsien-Wen
Chen Shu-fen
陳淑芬
author Chen Shu-fen
陳淑芬
spellingShingle Chen Shu-fen
陳淑芬
The Determination of Elements in the Serum and Tissue among Breast Tumor Patients
author_sort Chen Shu-fen
title The Determination of Elements in the Serum and Tissue among Breast Tumor Patients
title_short The Determination of Elements in the Serum and Tissue among Breast Tumor Patients
title_full The Determination of Elements in the Serum and Tissue among Breast Tumor Patients
title_fullStr The Determination of Elements in the Serum and Tissue among Breast Tumor Patients
title_full_unstemmed The Determination of Elements in the Serum and Tissue among Breast Tumor Patients
title_sort determination of elements in the serum and tissue among breast tumor patients
publishDate 1999
url http://ndltd.ncl.edu.tw/handle/05064317388461133349
work_keys_str_mv AT chenshufen thedeterminationofelementsintheserumandtissueamongbreasttumorpatients
AT chénshūfēn thedeterminationofelementsintheserumandtissueamongbreasttumorpatients
AT chenshufen rǔfángzhǒngliúhuànzhěxuèqīngjízǔzhīzhōngyuánsùzhīfēnxī
AT chénshūfēn rǔfángzhǒngliúhuànzhěxuèqīngjízǔzhīzhōngyuánsùzhīfēnxī
AT chenshufen determinationofelementsintheserumandtissueamongbreasttumorpatients
AT chénshūfēn determinationofelementsintheserumandtissueamongbreasttumorpatients
_version_ 1718177566470176768