| Summary: | 碩士 === 中國醫藥學院 === 環境醫學研究所 === 87 === Elements are vital to healthy functioning of body tissues. A surplus or lack of any element may have a detrimental effect on or interfere with immunological response, cell growth, pathological change and systemic organs. The objective of this study is to determine the elements in serum and tissue in breast tumor patients. The concentration of 15 elements in breast tumor cells were compared the concentrations in normal cells. This study can be used to start a database in Taiwan of element concentration in tissue and serum. All elements in serum and tissue were pretreated using microwaves and then analyzed using ICP-AES and AAS. The results showed that the concentrations of all 15 elements in tissue and serum were higher in breast tumor cells than in normal cells. The ratio of Cu/Zn increased with pathology of tumor cells. This ratio may be used as diagnostic tool for breast cancer. There are positive correlation between sera and tissues in Cr (r=0.37), Al (r=0.38) and ratio of Cu/Zn (r=0.36) from benign patients but only found in Al(r=0.43) from malignant breast tumor patients. Concentration of Zn, Cd, Cr, Al and Cu had statistical difference in different age strata. Based on the multiple regression, Zn concentration was higher in breeding or subjects who smoking compared to non-breeding and nonsmoker, respectively. There is a higher Mg concentration in sera among subjects with experience to nutrient taking. Compare tumor tissue to normal tissue, all element concentrations and ratios of Cu/Zn and Cu/Zn had significant difference. However, concentration of Cr, Mn, Fe, Mg and Al had significant difference between begin tissue and normal tissue. The authors suggest that further studies be conducted to establish a norm value of elements in human tissue in Taiwan in order to understand the relationship between tumor pattern and elements in human tissue and sera.
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