| Summary: | 碩士 === 台北醫學院 === 生藥學研究所 === 86 === Taiwan is located at the subtropical zone. It abounds with rainfull and
has numerous kinds of plants. It has the opportunity and conditions to develop
the natural products. The purpose of the present study was to develop the new
、effective and safe antibacterial infection natural source on skin. We h
ave collected ninty-four kinds of fresh leaves of folk medicine from Taipei、N
anto and Ilan. They were extracted with 70％ acetone, concentrated, frozen dry
, and then stored at -20℃。Using paper disc agar method and broth dilution me
thod, seven strains of staphylococcus genus, including staphylococcus aureus s
ubsp. aureus 、S. epidermidis、S. haemolyticus、S. xylosus、S. hominis、S. cap
itis subsp. capitis、S. cohnii subsp. cohnii were tested for antibacterial act
ivity. The diameter of inhibition zone wider than 10mm indicated positiv
e for antibacterial activity, 11-15mm moderate potency and 16-20mm show high a
ntibacterial potency. Our results indicated that fifty-three out of ninty-four
kinds folk medicine tested show antibacterial activity. Especially, Eugenia u
niflora has high activity against s. epidermidis, and Heimia myrtifolia、Termi
nalia catappa、T. bovinii、Ricinus communis and Syzygium formosanum had modera
te activity. We also conducted Samonella/microsome test to examine the th
e safety of the six materials which showed the antibacterial activity. The res
ult showed that Syzygium formosanum induced TA 98 mutation when S9 was added.
In contrast, Eugenia uniflora didn''t induce TA 98 mutation when S9 was added.
The remaining materials showed no mutation effect. All the six materials teste
d showed no mutation effect to TA100. Taken together, our results suggest that
Terminalia catappa、T. bovinii、Heimia myrtifolia 、Ricinus communis and Euge
nia uniflora have potential to be developed as the safe and effective antibact
erial materials in the furture.
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