| Summary: | 碩士 === 國立臺灣大學 === 免疫學研究所 === 86 === Naive T lymphocytes undergo priming when they first come into contact
with foreign antigen, a process referred to as functional differentiation.
This phenomenon is now believed to play an important role in the
regulation of immune response phenotype on human beings. Therefore,
it is important to know how to control the balance between two types
of the helper T cells.So far it is known that IL-12 and IL-4 can direct
Th1 and Th2 functional differentiation, respectively. Furthermore,
Interleukin-1 is known to be able to maintain Th2 cells proliferation
in vitro. However, the role of IL-1 in functional differentiation of
naive helper T cells is still unknown!
In!this study, we first demonstrated that if Na*ve T lymphocytes undergo
priming without IL-1 can differentiate and produce high levels of IFN-g
but low levels of IL-4 in second restimulation. In addition, we also
found this process is depend on APCs but not strickly depend on IL-4.
We also use the technique of in vivo gene transfection with cationic
liposomes to induce IL-1ra overexpression in the site where specific
immune response occured. IL-1ra can also promote antigen-specific IgG2a
and IFN-g production in vivo. All of these results suggest that IL-1 can
promote Th2-development. Thus, the balance between endogenous IL-1 and
IL-1ra in primary immune responses is a key factor in determining the
functional deviation of Th cells.
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