Enhancement of the Immunogenicity of Tumor Cells

• Main Authors: Cheng, Ting-Ying, 鄭婷英
• Other Authors: Rong-Hwa Lin
• Format: Others
• Language: en_US
• Published: 1998
• Online Access: http://ndltd.ncl.edu.tw/handle/48740541079922597714

博士 === 國立臺灣大學 === 微生物學研究所 === 86 === ABSTRACT The successful T cell responses against tumor are dependent on the molecular interaction between tumor cells and T cells and the cytokine repertoire present at the tumor site. It was demonstrated that the weak immunogenicity and the inefficiency of tumor cells in inducing tumor-specific T cells was resulted from insufficient expression of major histocompatibility complex (MHC) or accessory molecules. In the present study, we demonstrated that upregulating the expression of intercellular adhesion molecule-1 (ICAM-1) on tumor cells by the 8-MOP/UVA treatment could enhance the immunogenicity of tumor and resulted in growth inhibition of the unmodified tumor cells. Failure of an antitumor immune response could also be related to the defects of immune regulation at tumor site. Some tumor cells may secrete certain immunosuppressive factors to modify the host immune responses. Moreover, the inability of adequate activation of tumor-specific cytotoxic T cells might be due to the insufficient generation of tumor-specific Th cells which can provide the proper cytokine regulation at the tumor site. In our present investigation, we recruited and cognated tumor cells with OVA-primed Th cells by immunizing the OVA-sensitized mice with irradiated OVA-pulsed cells. We demonstrated here that the immunogenicity of tumor cells was augmented and the growth of the subsequently challenged tumor could be inhibited by tumor-specific CD8+ T cells.