Surface Characterization and Blood Compatibility Studies of Variation Functional Groups of Self Assembled Monolayer

• Main Authors: Chuang, Wen-Hsi, 莊文喜
• Other Authors: Jui-Che Lin
• Format: Others
• Language: zh-TW
• Published: 1998
• Online Access: http://ndltd.ncl.edu.tw/handle/12113126880729657857

碩士 === 國立成功大學 === 化學工程學系 === 86 === Abstract Self assembled monolayer（SAM）has been shown as a very well- ordered monolayer on the surface. Due to its well-defined surface chemical structure, it is employed as the model surface in this study to explore the relationships between the blood components and the various surface properties of substrate. Self assembled monolayers on gold substrate using the thiol with the hydrophobic terminal group, CH3(CH2)9SH, hydrophilic neutral terminal group, OH(CH2)11SH, and hydrophilic negative charge functional group,COOH(CH2)10SH, HSO3(CH2)10SH are employed for this study. Dynamic contact angle measurement indicates the SAM surface with -CH3 terminal group are hydrophobic and the surfaces with -OH, -COOH, and -SO3 terminal groups are hydrophilic. The C1S and S2p ESCA spectra confirm the functional groups composition and the S2p spectra further confirmed the formation of monolayer on the Au substrate. Platelet adhesion test demonstrates the SAM with hydrophobic function group (-CH3) exhibiting the highest degree of platelet activation. The SAM surface with -OH terminal group has been shown to induce the least degree of platelet activation and the least amount of platelet adhesion. Moreover, the SAM surfaces with negative charge functionalities have a similar amount of platelet adhesion but lower degree of platelet activation than the one with the hydrophobic group (-CH3). Key word：Self assembled monolayers, blood compatibility, wettability, platelet