Studies on The Antiplatelet Constitutents of Hypericum geminiflorum

• Main Authors: Weng, Jing-ru, 翁靖如
• Other Authors: Chun-Nan Lin
• Format: Others
• Language: zh-TW
• Published: 1998
• Online Access: http://ndltd.ncl.edu.tw/handle/82023997291724969274

碩士 === 高雄醫學院 === 藥學研究所 === 86 === The antiplatelet effects of four compounds isolated from the heartwood of Hypericum geminiflorum were studide on inhibitoryeffects on platelet aggregation induced by Arachidonic acid (AA),collagen, ADP, PAF in washed rabbit platelet. The new chalcones, gemichalcone A and B showed strong antiplatelet effects on AA-induced platelet aggregation, while known compounds, 2,6-dimethoxy-p-benzoquinone and cycloartopin showed potent antiplatelet effects on AA- and collagen-induced platelet aggregation. For a continual study of antiplelet agents of Chinese herbs, three new xanthones, 6,7-dihydroxy-1,3- imethoxyxanthone(6),4-hydroxy-1,2-dimethoxyxanthone(7), and gemixanthone A(9) and six known compounds, b-sitosterol(1), b- sitosterol-3-o-b-sitosterol(2), toxyloxanthone B(3), 1,5,6-trihydroxy-3-methoxyxanthone(4), 3,8-dihydroxy-1,2- dimethoxyxanthone(5), and 1,3,5,6-tetrahydroxyxanthone(8) were isolated and characterized from leaves and stems of Hypericum geminiflorum.