The effect of Son-Chi-Wang in Airway inflammation and Immunity after Dermatogoides Peteronyssinus

• Main Authors: Chens, Chao-Chung, 陳朝宗
• Other Authors: Koa, Shung-Te
• Format: Others
• Language: zh-TW
• Published: 1998
• Online Access: http://ndltd.ncl.edu.tw/handle/25264255942517287795

碩士 === 中國醫藥學院 === 中國醫學研究所 === 86 === Allergic asthma is one of the most common chronic diseases in the field of pediatrics in Taiwan. The 108 male Dunkin-Hartley guinea pigs, weighting 350-450gm were used in this study. Guinea pigs were sensitized intraperitoneally 100*g/ml by Der p at day 0、7 and challenged aerosolizedly 1mg/ml by Der p at day 21. San-chi-wang was administrated from day 25 to day 31 until the second challenge（day 32）. Acetylcholine provocation test, brochoalveolar analysis, pulmonary pathologic examination and one-way ANOVA were applied to evaluate the effect of San-Chi-Wang in asthmatic guinea pigs. The results showed: （1）Acetylcholine provocation test: The concentration of acetylcholine had significantly increased in treated group.（2）Brochoalveolar lavage analysis: 1)inflammation cells: The total number of macrophage had significantly decreased at 1、6、24、48 hour in treated group. 2)Inflammatory mediator: The concentration of PGE2 had significantly increased at 1 hour and LTC4 had decreased at 1、24 hour in treated group .3)T-lymphocyte: The numbers of CD3+、CD4+ T lymphocyte at 72 hours and CD8+ T lymphocyte at 1、72 hour were significantly increased in treated group.（3）Pulmonary histopathological finding: The inflammation cell infiltration of respiratory tract had decreased in treated group. According to above results, we suggest San-Chi-Wang can decrease the respiratory hyperreactivity and prevent moderately asthma attack.