The Therapeutic effect of Gypenoside Formulas on the Chronic Liver Injury and anti-oxidation induced by CCl4 in rats.

• Main Authors: Chen, Ming-Ho, 陳明和
• Other Authors: Chen, Jung-Chou
• Format: Others
• Language: zh-TW
• Published: 1998
• Online Access: http://ndltd.ncl.edu.tw/handle/76337904892136719487

碩士 === 中國醫藥學院 === 中國醫學研究所 === 86 === Gypenoside Formulas are the combination of four Chinese medicines, derived from the Gynostemma pentaphllum Makino, Schishandra chinensis Baill, Salvia mitiorrhiza Bge, and Prunus persica (L.) Batsch. We evaluate its hepatoprotective, antifibrotic and antioxidant potential in chronic liver injury induced by CCl4 for 8 weeks. The results indicate that the increase of sGOT and sGPT activities in CCl4 liver injury reduces significantly by treated with Gypenoside Formulas. These Formulas elevate the A/G ratio and also have the effect of reducing the collagen content by 40%. These phenomena are confirmed by pathologic observation, and the thinner bands of liver collagen are also find. The results suggest that these drugs are hepatoprotective and anti-fibrotic agents. And their effects of anti-oxidation are attribute to the potential of Gypenoside Formulas as a free radical scavenger that inhibit lipid peroxidation and elevate the level of catalase.