A Model of Artificial Stomach for Assessing the Antacid Effects on Traditional Chinese Medicines

• Main Authors: Lin, Toung-Lu, 林銅祿
• Other Authors: Kun-Ying Yen, Ling-Ling Yang
• Format: Others
• Language: zh-TW
• Published: 1997
• Online Access: http://ndltd.ncl.edu.tw/handle/75307799372242998854

碩士 === 台北醫學院 === 生藥學研究所 === 85 === Abstract There are many formulas for the treatment of gastric ulcer in the "Standarized Traditional Chinese Medicine Formulas". Among them, Si- Jun-Zi-Tang S.J.Z.T. is the representative one for gastric ulcer and An- Chong-San A.C.S. is the major formula for stomach and abdominal pain. These two formulas are commonly used by herbal medical doctors to treat gastric ulcer. The classical Fordtran test method until now the only one employed to evaluate antacid products, does not evaluate the duration of antacid action since it is only a quantitative method to determine Acid NeutralizinCapacity. We have tried to approach pysiological conditions, by constructing a model of an "Artificial Stomach" possessing some of the featured of a normal functioning stomach. This model was designed to account for some of the parameters lacking in conventional in vitro antacidevaluation. The antacid activity and effect on gastric bicarbonate secretioof S.J.Z.T. and A.C.S. were assessed with three different conditions our experiments have found that: 1. Fordtran's method experiment without hog stomach and without secretory and emptying flux: neutralization reaction was very fast and complete. without sustained reaction. both drugs exhibited weak antacid activity. A.C.S. was better than S.J. Z.T. on antacid activity. 2. Experiment without hog stomach but with secretory and emptying flux Increased the pH of artificial gastric fluid from pH1.2 to pH1.53 and pH1.46 respectively for A.C.S. and S.J.Z.T.Duration of antacid activity were 117minutes and 94mimutes respectively for A.C.S. and S.J.Z.T. These findings indicate that the mechanism of antacid activity of S.J.Z.T. and A.C.S. were the same, namely neutralization; no buffer capacity was found. 3.Experiment with hog stomach but without secretory and emptying flux using water as blank and aluminium phosphate gel as cortrol, the antacid activity of both drugs were found partly from their promoting effect on gastric bicarbonate secretion by surface epithelial cell. compared with blank the pH rose 43.66%、28.17% and this effect was significant. The results of this study suggested that besides weak antacid activity.A.C.S. and S.J.Z.T. also possess the protective action on gastric mucosa. Keywords: Peptic ulcer, Artificial Stomach, Traditional Chinese Medicine Formulas, Si-Jun-Zi-Tang,(S.J.Z.T.) An- Chong-San(A.C.S.).