| Summary: | 碩士 === 台北醫學院 === 生藥學研究所 === 85 === Abstract
There are many formulas for the treatment of gastric ulcer in
the "Standarized Traditional Chinese Medicine Formulas".
Among them, Si- Jun-Zi-Tang S.J.Z.T. is the representative
one for gastric ulcer and An- Chong-San A.C.S. is the major
formula for stomach and abdominal pain. These two formulas
are commonly used by herbal medical doctors to treat gastric
ulcer.
The classical Fordtran test method until now the only one
employed to evaluate antacid products, does not evaluate the
duration of antacid action since it is only a quantitative
method to determine Acid NeutralizinCapacity. We have tried to
approach pysiological conditions, by constructing a
model of an "Artificial Stomach" possessing some of the
featured of a normal functioning stomach. This model was
designed to account for some of the parameters lacking in
conventional in vitro antacidevaluation. The antacid activity
and effect on gastric bicarbonate secretioof S.J.Z.T. and A.C.S.
were assessed with three different conditions our experiments
have found that:
1. Fordtran's method experiment without hog stomach and without
secretory and emptying flux: neutralization reaction was very
fast and complete. without sustained reaction. both drugs
exhibited weak antacid activity. A.C.S. was better than S.J.
Z.T. on antacid activity. 2. Experiment without hog
stomach but with secretory and emptying flux Increased the
pH of artificial gastric fluid from pH1.2 to pH1.53 and
pH1.46 respectively for A.C.S. and S.J.Z.T.Duration of antacid
activity were 117minutes and 94mimutes respectively for A.C.S.
and S.J.Z.T.
These findings indicate that the mechanism of antacid activity
of S.J.Z.T. and A.C.S. were the same, namely neutralization;
no buffer capacity was found.
3.Experiment with hog stomach but without secretory and emptying
flux using water as blank and aluminium phosphate gel as
cortrol, the antacid
activity of both drugs were found partly from their promoting
effect on gastric bicarbonate secretion by surface epithelial
cell. compared with blank the pH rose 43.66%、28.17% and this
effect was significant. The results of this study
suggested that besides weak antacid activity.A.C.S. and
S.J.Z.T. also possess the protective action on gastric mucosa.
Keywords: Peptic ulcer, Artificial Stomach, Traditional Chinese
Medicine Formulas, Si-Jun-Zi-Tang,(S.J.Z.T.) An-
Chong-San(A.C.S.).
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