| Summary: | 碩士 === 台北醫學院 === 醫學研究所 === 85 === The objective of this study is to elucidate the association
among ischemic heart disease,chronic arsenic exposure indices,
serum micronutrients(vitaminA, vitamin E, lycopene, α-carotene,
β-carotene), urinary arsenic species(AsIII,DMA, MMA and AsV)
and other risk factors. 74 prevalence cases of ischemic heart
disease and 193 age-sex-matched healthy controls were selected
from a study cohort of residents lived in three villages where
blackfoot disease was hyperendemic. Urinary arsenic species were
isolated by high performance liquid chromatography.(HPLC) and
determined by automic absorption spectrometry(AAS). Serum
micronutrients were determined by Htomic absorption
spectrometry. There was no significant difference between
urinary arsenic species and ischemic heart disease except total
arsenic level. A significant dose-response relationship was
observed between ischemic heart disease and drinking high-
arsenic artesian well water.The relation was boarderline
significant after adjustment for age,sex,α-caroteneor β-
carotene, total cholesterol level, body mass index(BMI) and
hypertension. There was a negtive dose-response relationship
between α-carotene or β-caroteneand ischemic heart diseas. The
relation on β-carotene was also significant and α-carotene was
boraderline significant after adjustment for age, sex,
drinkinghigh-arsenic artesian well water, total cholesterol, BNI
and hypertension. Otherrisk factors, except hypertention, such
as serum triglyceride, cholesterol, high density lipoprotein,
low density lipoprotein, apolipoprotein A1, apolipoprotein B
concentration, smoking, alcohol drinking, and liver function
indices, had no significant association with ischemic heart
diseas.
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