Effects of weight reductiion on body composition, energy metabolism and blood chemistry of obese women

• Main Authors: Liu, Mei-Yuan, 劉美媛
• Other Authors: Ye, Song-Ling
• Format: Others
• Language: zh-TW
• Published: 1997
• Online Access: http://ndltd.ncl.edu.tw/handle/41381529073719054287

碩士 === 台北醫學院 === 保健營養學研究所 === 85 === Epidemiological studies have shown that obesity has positive correlation with the incidence of chronic diseases, and weight reduction ameliorate the severi ty of the diseases. Domestic studies about the various comparisons before and after weight reduction are rare. The aim of this study was to investigate th e changes in body composition, energy metabolism and biochemical indices befor e and after weight reduction. Besides, the possible advantages of weight redu ction were also discussed. Sixty-seven premenopausal obese women were recruit ed into our study for a weight reduction program for one half to one year peri od. Eighteen normal weight age matched women served as control. The body mas s index (BMI) of control group was 19.8-24.2. Women whose BMI ranged from 26. 4 to 30.7 were classified as mildly obese group (n=44), and that with BMI > 3 0.8 were regarded as moderately obese group (n=23).The results of this study i ndicated that body fat mass (FM), fat free mass (FFM) and resting metabolic r ate (RMR) were significantly different among the normal weight, mildly obese a nd moderately obese groups, and these parameters were increased in accordance with the body weight. There was no difference in RMR/FFM ratio among the thre e groups. However, the ratio of RMR/BW was significantly lower in obese group s than that of the normal weight group. This finding may suggest that obese w omen have relatively hypometabolic response compared with the normal weight wo men.Among the 67 subjects only 29 subjects reduced weight for more than 5% of their initial body weight, and the mean weight loss of there subjects were 9.2 ±5.2kg. Body fat content was reduced for 3.6±2.3% after weight reduction. No significant difference in urinary creatinine and 3-methylhisitidine were se en between the subjects before and weight reduction, this may suggest that wei ght reduction did not enhance muscle breakdown under the present study. Plasm a triglyceride (TG), total cholesterol (TC), low density lipoprotein cholester ol (LDL-C), Apolipoprotein B (Apo B) and insulin concentrations were significa ntly higher and high density lipoprotein cholesterol (HDL-C) were lower in mod erately obese group than the normal weight group. Weight reduction of the obe se subjects significantly lower the plasma TG, TC, LDL-C. HDL-C was significa ntly increased after weight reduction. However, the concentration of HDL-C of the obese groups was still lower than the normal weight group. In conclusion, body FM, FFM and RMR were significantly higher in obese groups than that of t he normal weight group. Since RMR/BW was significantly lower in obese groups than the normal weight group, it might mean that obese women have relatively h ypometabolic response than normal weight women. Weight reduction in obese sub jects significantly decrease FM, FFM and RMR. Considering that urinary creati nine and 3-methylhisitidine did not different between subjects before and afte r weight reduction, it was thought that muscle breakdown was not increased du ring weight reduction. The results of this study revealed that plasma TG, TC, LDL-C and insulin concentration were significantly higher and HDL-C was lower in obese groups than normal weight group. Weight reduction for more than 5% o f initial body weight can significantly reduced plasma lipids, insulin, gluco se and uric acid concentration and may improve the overall health condition of the individual subject.