| Summary: | 碩士 === 台北醫學院 === 保健營養學研究所 === 85 === Epidemiological studies have shown that obesity has positive
correlation with the incidence of chronic diseases, and
weight reduction ameliorate the severi ty of the diseases.
Domestic studies about the various comparisons before and
after weight reduction are rare. The aim of this study was to
investigate th e changes in body composition, energy
metabolism and biochemical indices befor e and after weight
reduction. Besides, the possible advantages of weight redu
ction were also discussed. Sixty-seven premenopausal obese
women were recruit ed into our study for a weight reduction
program for one half to one year peri od. Eighteen normal
weight age matched women served as control. The body mas s
index (BMI) of control group was 19.8-24.2. Women whose BMI
ranged from 26. 4 to 30.7 were classified as mildly obese
group (n=44), and that with BMI > 3 0.8 were regarded as
moderately obese group (n=23).The results of this study i
ndicated that body fat mass (FM), fat free mass (FFM) and
resting metabolic r ate (RMR) were significantly different
among the normal weight, mildly obese a nd moderately obese
groups, and these parameters were increased in accordance
with the body weight. There was no difference in RMR/FFM ratio
among the thre e groups. However, the ratio of RMR/BW was
significantly lower in obese group s than that of the normal
weight group. This finding may suggest that obese w omen have
relatively hypometabolic response compared with the normal
weight wo men.Among the 67 subjects only 29 subjects reduced
weight for more than 5% of their initial body weight, and the
mean weight loss of there subjects were 9.2 ±5.2kg. Body fat
content was reduced for 3.6±2.3% after weight reduction. No
significant difference in urinary creatinine and
3-methylhisitidine were se en between the subjects before and
weight reduction, this may suggest that wei ght reduction did
not enhance muscle breakdown under the present study. Plasm a
triglyceride (TG), total cholesterol (TC), low density
lipoprotein cholester ol (LDL-C), Apolipoprotein B (Apo B) and
insulin concentrations were significa ntly higher and high
density lipoprotein cholesterol (HDL-C) were lower in mod
erately obese group than the normal weight group. Weight
reduction of the obe se subjects significantly lower the
plasma TG, TC, LDL-C. HDL-C was significa ntly increased
after weight reduction. However, the concentration of HDL-C of
the obese groups was still lower than the normal weight group.
In conclusion, body FM, FFM and RMR were significantly higher
in obese groups than that of t he normal weight group. Since
RMR/BW was significantly lower in obese groups than the
normal weight group, it might mean that obese women have
relatively h ypometabolic response than normal weight women.
Weight reduction in obese sub jects significantly decrease FM,
FFM and RMR. Considering that urinary creati nine and
3-methylhisitidine did not different between subjects before and
afte r weight reduction, it was thought that muscle breakdown
was not increased du ring weight reduction. The results of
this study revealed that plasma TG, TC, LDL-C and insulin
concentration were significantly higher and HDL-C was lower
in obese groups than normal weight group. Weight reduction for
more than 5% o f initial body weight can significantly
reduced plasma lipids, insulin, gluco se and uric acid
concentration and may improve the overall health condition of
the individual subject.
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