Studies on the constituents from stems of Litsea lancifolia (Roxb.ex Nees), Benth. et Hook. f. ex F. Vill.

• Main Authors: Liu, Li Yu, 劉俐余
• Other Authors: Karin Chiung-Sheue Chen , Shoei-Sheng Lee
• Format: Others
• Language: zh-TW
• Published: 1997
• Online Access: http://ndltd.ncl.edu.tw/handle/58554538504421207752

碩士 === 國立臺灣大學 === 藥學系 === 85 === Lauraceous plants of Litsea genus are noted for the existence of various isoquinolines. Except this, only few studies were undertaken on other constituents. To fill in this vacancy and explore further the potential of these natural resources, this thesis was aimed to study for the first time the chemical ingredients in Litsea lancifolia (Roxb.ex Nees) Benth. et Hook. f. ex F. Vill. The alcoholic extracts from the stems of this plant were triturated with water,5% HOAc, and 50% MeOH/ water in sequence. The final residue was subsequently fractionated with n-hexane, chlorform and methanol. The chloroform soluble fraction was chromatographed repeatedly over silica gel column, Sephadex LH-20 column, HPLC and preparative TLC. These efforts led to the isolation of 14 compounds. The structural elucidation of these compounds was identified by spectral analysis(mainly 1H-NMR, 13C-NMR and 2D NMR). According to the structures,these compounds were classified into four categories: 1. Aliphatic compounds and their derivatives: 2. butyl stearate (1), 1-hexacosanol (2), (-hydroxy hexacosanoic acid (3), tetracosanyl cis-ferulate (4), tetracosanyl trans-ferulate (5), 28-feruloyloxy octacosanoic acid 1-monoglyceride (6). 2.Lignans: 9''-O-trans-feruloyl-5,5''-dimethoxy-lariciresinol (7) , 9,9''-O-diferuloyl-secoisolariciresinol (8), 9,9''-O- diferuloyl-5,5''-dimethoxy-secoisolariciresinol (9) 3. 3.Alkaloids: thalbaicaline (10), atheroline (11), dehydrothalbaicaline (12). 4. Lactonic compounds: litsenolide B2 (13), compound (14). To our knowledge, compounds (12) and (14) are novel natural products.