In vitro and in vivo antiplatelat effects of YC-1,a NO- independent activator of slouble guanylate cyclase
博士 === 國立臺灣大學 === 藥理學研究所 === 85 === YC-1, a derivative of benzylindazole , activates soluble guanylate cyclase (sGC) of human platelets by a NO-independent mechanism, and exerts its inhibitory effects on platelet aggregation and adhesion through the sGC/...
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| Other Authors: | |
| Format: | Others |
| Language: | zh-TW |
| Published: |
1997
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| Online Access: | http://ndltd.ncl.edu.tw/handle/93048516638124992922 |
| Summary: | 博士 === 國立臺灣大學 === 藥理學研究所 === 85 === YC-1, a derivative of benzylindazole , activates soluble
guanylate cyclase (sGC) of human platelets by a NO-independent
mechanism, and exerts its inhibitory effects on platelet
aggregation and adhesion through the sGC/cGMP pathway.
Furthermore, YC-1 is an effective antigyrombotic agent in
preventing thrombosis in animal models , and its
antiaggregating and additional prefibrinolytic efectsmay be of
potential clinical benefit in the treatment of thromboembolic
diseases.
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