Determination and carcinogenic risk assessment of organochlorine pesticides in foods

• Main Authors: Lee, Chen-yeu, 李陳宇
• Other Authors: Doong Ruey-an
• Format: Others
• Language: zh-TW
• Published: 1997
• Online Access: http://ndltd.ncl.edu.tw/handle/04304671215803979328

碩士 === 國立清華大學 === 原子科學系 === 85 === Organochlorine pesticides (OCPs) were widely used for pasts control in agriculture for the past few decades . Their application has increased corp yields and has improved the quantity of foods in the diet. However, organochlorine pesticides can cause a range of adverse effects on human health, such as cancer, genic effect and acute and chronic injury to the nervous system. To estimate Taiwanese daily intakes and assess the carcinogenic risk of organochlorine pesticides in foods , such as BHC, heptachlor, aldrin,heptachlor epoxide, endosulfan, DDE, dieldrin, endrin, DDD and DDT in food,meat, fish and seafood were analyzed as major sources of these pesticidesin the diet. Five clean-up procedures were evaluated to determine the suitable packing material. Results shown that the average recoveries of clean-up by Envi-Carb, Envi-18, tandem column (Envi-18 and Florisil), Alumina-N and Florisil ranged from 15 to 150%, 52 to 94%, 63 to 139%,48 to 101% and 63 to 122%, respectively. The Florisil cartridge was shown to have less matrix effects and high recoveries of OCPs and was choosed ofthis research. By using Florisil, the average recoveries of meat, fish and seafood ranged from 69 to 125%, 51 to 105% and 69 to 125%. The OCPs residue in meat, fish and seafood are ranged from 0.32 to 10.22 ng/g, 0.89 to 13.9 ng/g and 0.26 to 6.45 ng/g, respectively . Fromthe analytical results of this study, meat, fish and seafood are demonstrated to be relatively high hazardous materials for human. The high exposure frequency of OCPs by meat, fish and seafood are endosulfan(I)(51.4) and heptachlor epoxide(47.6%).The carcinogenic risk of the fish and pork are 91.1*10-6 and 132*10-6, respectively. The total carcinogenic risk of foods in this research is 251*10-6.