Studies on the preparation of microcapsules of water-soluble drug by using two-steps coating method

• Main Authors: Chung, Shou Chang, 鍾守昌
• Other Authors: Hui Chen
• Format: Others
• Language: zh-TW
• Published: 1997
• Online Access: http://ndltd.ncl.edu.tw/handle/68816843135744335084

碩士 === 國立中央大學 === 化學工程學系 === 85 === AbstractThe preparation of spherical microcapsules by using two- steps coating method was developed. By the two-steps coating method ,the drug loss can be reduced. The following effects, the different core wall ratio of microcapsules, the drug loss of microcapsules and the behavior of drug release were studied. This project also studied the size distribution ,drug contents and release rateof different products and their surface structure by SEM. Furthermore, the release kinetic patterns of different microcapsules were studied.The results indicates that the drug loss reduced from 54.3% to 41.2% by using two-steps coating method. Dissolution studies showed that the range of T20(the time at which 20% of the drug is released) of microcapsules prepared by two-steps coatiog method was from 2h to 35.4h.The range of T20 of microcapsules prepared with pure TH was from 2.7h to 7.7h. The drug release of the same series microcapsules reduced with the increase of EC.With over amount of EC, there would have inverse phenomena. However,the release behavior of various microcapsules fitted the first order release model and Higuchi spherical matrix release model. And the release behavior of microcapsules prepared by two-steps coating method fitted the zero order release model.